Сегодня у онкологических пациентов есть шанс получить эффективную химиотерапию в Израиле абсолютно бесплатно . Американская фармацевтическая компания Eli Lilly and Company разработала противоопухолевый препарат Абемациклиб (abemaciclib) ставший новым словом в лечении некоторых видов рака молочной железы. Клинические испытания в США показали его высокую эффективность в отношении HR+ (гормон-рецептор-положительного) рака молочной железы , что подтверждено Управлением контроля качества продуктов и лекарственных средств США (Food and Drug Administration, FDA). В данный момент в Израиле планируется клиническое испытание под руководством выдающегося израильского доктора - руководителя Луна Кадури ,
для которого набираются группы пациентов с разными формами онкологических заболеваний:
Метастатический HR+ и HER2+ рак молочной железы, Метастатический HR+ и HER2- рак молочной железы, Немелкоклеточный рак легкого Меланома при показаниях к хирургическому удалению метастазов в головном мозге Меланома при наличии лептоменингеальные метастазов Принцип действия Абемациклиба
Абемациклиб блокирует ферменты CDK4 и CDK6, которые играют важную роль в делении злокачественных клеток. В результате, рост опухоли прекращается, а ее ткани разрушаются. Предполагается, что препарат станет высокоэффективным средством в лечении рака молочной железы , немелкоклеточного рака легкого и меланомы , в том числе с метастазами.
Требования к пациентам-участникам исследования:
Возраст старше 18 лет; Отсутствие беременности или планов на зачатие в последующие за лечением 3 месяца, также не допускаются женщины, кормящие грудью; Наличие диагностированного и подтвержденного онкологического заболевания, входящего в перечень выбранных для исследования; Отсутствие сердечно-сосудистых и инфекционных заболеваний. Ход исследования
Срок проведения исследования составляет 21 день, в течение которых пациент принимает Абемациклиб 2 раза в сутки. Курс экспериментального лечения может быть прерван по желанию пациента или при развитии реакций на препарат, ухудшении самочувствия. При положительном эффекте приема Абемациклиба может быть рассмотрено решение о продолжении терапии.
Организация участия в исследовании
На сайте DocLand. ru
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для которого набираются группы пациентов с разными формами онкологических заболеваний:
Метастатический HR+ и HER2+ рак молочной железы, Метастатический HR+ и HER2- рак молочной железы, Немелкоклеточный рак легкого Меланома при показаниях к хирургическому удалению метастазов в головном мозге Меланома при наличии лептоменингеальные метастазов Принцип действия Абемациклиба
Абемациклиб блокирует ферменты CDK4 и CDK6, которые играют важную роль в делении злокачественных клеток. В результате, рост опухоли прекращается, а ее ткани разрушаются. Предполагается, что препарат станет высокоэффективным средством в лечении рака молочной железы , немелкоклеточного рака легкого и меланомы , в том числе с метастазами.
Требования к пациентам-участникам исследования:
Возраст старше 18 лет; Отсутствие беременности или планов на зачатие в последующие за лечением 3 месяца, также не допускаются женщины, кормящие грудью; Наличие диагностированного и подтвержденного онкологического заболевания, входящего в перечень выбранных для исследования; Отсутствие сердечно-сосудистых и инфекционных заболеваний. Ход исследования
Срок проведения исследования составляет 21 день, в течение которых пациент принимает Абемациклиб 2 раза в сутки. Курс экспериментального лечения может быть прерван по желанию пациента или при развитии реакций на препарат, ухудшении самочувствия. При положительном эффекте приема Абемациклиба может быть рассмотрено решение о продолжении терапии.
Организация участия в исследовании
На сайте DocLand. ru
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для которого набираются группы пациентов с разными формами онкологических заболеваний:
Метастатический HR+ и HER2+ рак молочной железы, Метастатический HR+ и HER2- рак молочной железы, Немелкоклеточный рак легкого Меланома при показаниях к хирургическому удалению метастазов в головном мозге Меланома при наличии лептоменингеальные метастазов Принцип действия Абемациклиба
Абемациклиб блокирует ферменты CDK4 и CDK6, которые играют важную роль в делении злокачественных клеток. В результате, рост опухоли прекращается, а ее ткани разрушаются. Предполагается, что препарат станет высокоэффективным средством в лечении рака молочной железы , немелкоклеточного рака легкого и меланомы , в том числе с метастазами.
Требования к пациентам-участникам исследования:
Возраст старше 18 лет; Отсутствие беременности или планов на зачатие в последующие за лечением 3 месяца, также не допускаются женщины, кормящие грудью; Наличие диагностированного и подтвержденного онкологического заболевания, входящего в перечень выбранных для исследования; Отсутствие сердечно-сосудистых и инфекционных заболеваний. Ход исследования
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Организация участия в исследовании
На сайте DocLand. ru
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NULL
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object(yii\redis\Connection)#30 (14) {
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NULL
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string(8) "BITFIELD"
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string(5) "BRPOP"
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string(10) "BRPOPLPUSH"
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string(11) "CLIENT KILL"
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string(11) "CLIENT LIST"
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string(14) "CLIENT GETNAME"
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string(12) "CLIENT REPLY"
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string(16) "CLUSTER DELSLOTS"
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string(16) "CLUSTER FAILOVER"
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string(14) "CLUSTER FORGET"
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string(21) "CLUSTER GETKEYSINSLOT"
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string(12) "CLUSTER INFO"
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string(15) "CLUSTER KEYSLOT"
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string(12) "CLUSTER MEET"
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string(13) "CLUSTER NODES"
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string(13) "CLUSTER RESET"
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string(14) "CLUSTER SLAVES"
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string(13) "CLUSTER SLOTS"
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string(12) "COMMAND INFO"
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string(10) "CONFIG GET"
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string(14) "CONFIG REWRITE"
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string(10) "CONFIG SET"
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string(6) "DBSIZE"
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string(6) "DECRBY"
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string(7) "DISCARD"
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string(4) "DUMP"
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string(4) "ECHO"
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string(7) "EVALSHA"
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string(4) "EXEC"
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string(6) "EXISTS"
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string(6) "EXPIRE"
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string(8) "EXPIREAT"
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string(8) "FLUSHALL"
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string(7) "FLUSHDB"
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string(6) "GEOADD"
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string(7) "GEOHASH"
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string(6) "GEOPOS"
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string(7) "GEODIST"
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string(9) "GEORADIUS"
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string(17) "GEORADIUSBYMEMBER"
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string(3) "GET"
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string(6) "GETBIT"
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string(8) "GETRANGE"
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string(6) "GETSET"
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string(4) "HDEL"
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string(7) "HEXISTS"
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string(4) "HGET"
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string(7) "HGETALL"
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string(7) "HINCRBY"
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string(12) "HINCRBYFLOAT"
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string(5) "HKEYS"
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string(4) "HLEN"
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string(5) "HMGET"
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string(5) "HMSET"
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string(4) "HSET"
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string(6) "HSETNX"
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string(7) "HSTRLEN"
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string(5) "HVALS"
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string(4) "INCR"
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string(6) "INCRBY"
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string(11) "INCRBYFLOAT"
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string(4) "INFO"
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string(4) "KEYS"
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string(8) "LASTSAVE"
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string(6) "LINDEX"
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string(7) "LINSERT"
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string(4) "LLEN"
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string(4) "LPOP"
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string(5) "LPUSH"
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string(6) "LPUSHX"
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string(6) "LRANGE"
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string(4) "LREM"
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string(4) "LSET"
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string(5) "LTRIM"
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string(4) "MGET"
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string(7) "MIGRATE"
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string(7) "MONITOR"
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string(4) "MOVE"
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string(4) "MSET"
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string(6) "MSETNX"
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string(5) "MULTI"
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string(6) "OBJECT"
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string(7) "PERSIST"
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string(7) "PEXPIRE"
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string(9) "PEXPIREAT"
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string(5) "PFADD"
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string(7) "PFCOUNT"
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string(7) "PFMERGE"
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string(4) "PING"
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string(6) "PSETEX"
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string(10) "PSUBSCRIBE"
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string(6) "PUBSUB"
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string(4) "PTTL"
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string(7) "PUBLISH"
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string(12) "PUNSUBSCRIBE"
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string(4) "QUIT"
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string(9) "RANDOMKEY"
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string(8) "READONLY"
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string(9) "READWRITE"
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string(6) "RENAME"
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string(8) "RENAMENX"
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string(7) "RESTORE"
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string(4) "ROLE"
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string(4) "RPOP"
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string(9) "RPOPLPUSH"
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string(5) "RPUSH"
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string(6) "RPUSHX"
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string(4) "SAVE"
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string(5) "SCARD"
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string(12) "SCRIPT DEBUG"
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string(13) "SCRIPT EXISTS"
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string(12) "SCRIPT FLUSH"
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string(11) "SCRIPT KILL"
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string(11) "SCRIPT LOAD"
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string(5) "SDIFF"
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string(10) "SDIFFSTORE"
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string(6) "SELECT"
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string(8) "SHUTDOWN"
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string(6) "SINTER"
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string(11) "SINTERSTORE"
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string(9) "SISMEMBER"
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string(7) "SLAVEOF"
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string(7) "SLOWLOG"
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string(4) "SORT"
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string(4) "SPOP"
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string(4) "SREM"
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string(6) "STRLEN"
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string(6) "SUNION"
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string(6) "SWAPDB"
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string(4) "SYNC"
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string(4) "TIME"
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string(5) "TOUCH"
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string(4) "TYPE"
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string(6) "UNLINK"
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string(7) "UNWATCH"
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string(4) "WAIT"
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string(5) "WATCH"
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string(5) "ZCARD"
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string(7) "ZINCRBY"
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string(11) "ZINTERSTORE"
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string(9) "ZLEXCOUNT"
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string(6) "ZRANGE"
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string(11) "ZRANGEBYLEX"
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string(14) "ZREVRANGEBYLEX"
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string(13) "ZRANGEBYSCORE"
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string(5) "ZRANK"
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string(4) "ZREM"
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string(14) "ZREMRANGEBYLEX"
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string(15) "ZREMRANGEBYRANK"
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string(16) "ZREMRANGEBYSCORE"
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string(9) "ZREVRANGE"
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string(16) "ZREVRANGEBYSCORE"
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string(8) "ZREVRANK"
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string(6) "ZSCORE"
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string(11) "ZUNIONSTORE"
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string(4) "SCAN"
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string(5) "SSCAN"
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string(5) "HSCAN"
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string(5) "ZSCAN"
}
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["_template":"yii\web\UrlRule":private]=>
string(32) "////"
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string(71) "#^(?Ppartner)/(?P[^\/]+)/(?P[^\/]+)$#u"
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(3) {
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string(8) ""
["controller"]=>
string(12) ""
["action"]=>
string(8) ""
}
}
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object(yii\web\UrlRule)#38 (16) {
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string(9) "countries"
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string(14) "#^countries$#u"
["host"]=>
NULL
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string(13) "country/index"
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array(0) {
}
["suffix"]=>
NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
}
["_template":"yii\web\UrlRule":private]=>
string(11) "/countries/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
}
}
[9]=>
object(yii\web\UrlRule)#39 (16) {
["name"]=>
string(7) "clinics"
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string(12) "#^clinics$#u"
["host"]=>
NULL
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string(12) "search/index"
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array(0) {
}
["suffix"]=>
NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
}
["_template":"yii\web\UrlRule":private]=>
string(9) "/clinics/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
}
}
[10]=>
object(yii\web\UrlRule)#40 (16) {
["name"]=>
string(9) "illnesses"
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string(14) "#^illnesses$#u"
["host"]=>
NULL
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string(13) "disease/index"
["defaults"]=>
array(0) {
}
["suffix"]=>
NULL
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NULL
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NULL
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bool(true)
["normalizer"]=>
NULL
["createStatus":protected]=>
int(2)
["placeholders":protected]=>
array(0) {
}
["_template":"yii\web\UrlRule":private]=>
string(11) "/illnesses/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
}
}
[11]=>
object(yii\web\UrlRule)#41 (16) {
["name"]=>
string(12) "certificates"
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string(17) "#^certificates$#u"
["host"]=>
NULL
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string(17) "certificate/index"
["defaults"]=>
array(0) {
}
["suffix"]=>
NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
}
["_template":"yii\web\UrlRule":private]=>
string(14) "/certificates/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
}
}
[12]=>
object(yii\web\UrlRule)#42 (16) {
["name"]=>
string(19) "certificates/[^\/]+)$#u"
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NULL
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string(16) "certificate/view"
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array(0) {
}
["suffix"]=>
NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(1) {
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string(4) "link"
}
["_template":"yii\web\UrlRule":private]=>
string(21) "/certificates/"
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string(41) "#^blog/tags/(?P[a-z0-9\-]+)$#u"
["host"]=>
NULL
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string(9) "blog/tags"
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array(0) {
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NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(1) {
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string(14) "tagRewriteName"
}
["_template":"yii\web\UrlRule":private]=>
string(28) "/blog/tags//"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(1) {
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string(16) "#^[a-z0-9\-]+$#u"
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[14]=>
object(yii\web\UrlRule)#44 (16) {
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string(9) "blog/tags"
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string(14) "#^blog/tags$#u"
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NULL
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string(10) "blog/cloud"
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array(0) {
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
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string(11) "/blog/tags/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
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array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[15]=>
object(yii\web\UrlRule)#45 (16) {
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string(20) "blog/page/"
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NULL
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array(0) {
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NULL
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NULL
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bool(true)
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int(2)
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array(1) {
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string(4) "page"
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string(18) "/blog/page//"
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NULL
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array(1) {
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string(8) "#^\d+$#u"
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[16]=>
object(yii\web\UrlRule)#46 (16) {
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string(29) "blog/"
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NULL
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NULL
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bool(true)
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int(2)
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array(1) {
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string(11) "rewriteName"
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string(20) "/blog//"
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NULL
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array(1) {
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string(16) "#^[a-z0-9\-]+$#u"
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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object(yii\web\UrlRule)#47 (16) {
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bool(true)
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NULL
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int(2)
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array(0) {
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string(6) "/blog/"
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NULL
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array(0) {
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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object(yii\web\UrlRule)#48 (16) {
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NULL
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array(0) {
}
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NULL
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NULL
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bool(true)
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int(2)
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array(3) {
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string(10) "branchLink"
}
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string(47) "/sitemap////"
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NULL
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array(3) {
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string(0) ""
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string(0) ""
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string(0) ""
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
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object(yii\web\UrlRule)#49 (16) {
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NULL
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array(0) {
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[20]=>
object(app\components\DoctorUrlRule)#50 (0) {
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[21]=>
object(app\components\SpecialityUrlRule)#51 (0) {
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object(app\components\CountryUrlRule)#52 (0) {
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[23]=>
object(app\components\CityUrlRule)#53 (0) {
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[24]=>
object(app\components\DiseaseUrlRule)#54 (0) {
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[25]=>
object(app\components\BranchUrlRule)#55 (0) {
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[26]=>
object(app\components\ClinicUrlRule)#56 (0) {
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string(5) "BRPOP"
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string(10) "BRPOPLPUSH"
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string(11) "CLIENT KILL"
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string(11) "CLIENT LIST"
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string(14) "CLIENT GETNAME"
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string(12) "CLIENT PAUSE"
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string(12) "CLIENT REPLY"
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string(14) "CLIENT SETNAME"
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string(16) "CLUSTER ADDSLOTS"
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string(16) "CLUSTER DELSLOTS"
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string(16) "CLUSTER FAILOVER"
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string(21) "CLUSTER GETKEYSINSLOT"
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string(12) "CLUSTER INFO"
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string(15) "CLUSTER KEYSLOT"
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string(12) "CLUSTER MEET"
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string(13) "CLUSTER NODES"
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string(13) "CLUSTER RESET"
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string(18) "CLUSTER SAVECONFIG"
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string(15) "CLUSTER SETSLOT"
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string(13) "CLUSTER SLOTS"
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string(12) "COMMAND INFO"
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string(10) "CONFIG GET"
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string(14) "CONFIG REWRITE"
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string(10) "CONFIG SET"
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string(6) "DBSIZE"
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string(12) "DEBUG OBJECT"
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string(14) "DEBUG SEGFAULT"
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string(6) "DECRBY"
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string(4) "ECHO"
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string(7) "EVALSHA"
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string(4) "EXEC"
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string(6) "EXPIRE"
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string(8) "FLUSHALL"
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string(6) "GEOADD"
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string(7) "GEOHASH"
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string(6) "GEOPOS"
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string(9) "GEORADIUS"
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string(17) "GEORADIUSBYMEMBER"
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string(3) "GET"
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string(8) "GETRANGE"
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string(6) "GETSET"
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string(7) "HEXISTS"
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string(4) "HGET"
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string(7) "HGETALL"
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string(7) "HINCRBY"
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string(12) "HINCRBYFLOAT"
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string(5) "HKEYS"
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string(4) "HLEN"
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string(5) "HMGET"
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string(4) "HSET"
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string(6) "HSETNX"
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string(7) "HSTRLEN"
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string(5) "HVALS"
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string(6) "INCRBY"
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string(11) "INCRBYFLOAT"
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string(4) "LLEN"
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string(4) "LPOP"
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string(6) "LRANGE"
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string(4) "LREM"
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string(4) "MGET"
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string(7) "MONITOR"
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string(4) "MOVE"
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string(4) "MSET"
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string(6) "MSETNX"
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string(5) "MULTI"
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string(6) "OBJECT"
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string(7) "PERSIST"
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string(7) "PFCOUNT"
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string(6) "PUBSUB"
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string(7) "PUBLISH"
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string(12) "PUNSUBSCRIBE"
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string(4) "QUIT"
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string(9) "RANDOMKEY"
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string(8) "READONLY"
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string(9) "READWRITE"
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string(6) "RENAME"
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string(8) "RENAMENX"
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string(7) "RESTORE"
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string(4) "ROLE"
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string(12) "SCRIPT DEBUG"
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string(13) "SCRIPT EXISTS"
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string(12) "SCRIPT FLUSH"
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string(11) "SCRIPT LOAD"
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string(6) "SELECT"
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string(4) "SREM"
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string(4) "TYPE"
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string(6) "UNLINK"
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string(7) "UNWATCH"
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string(5) "ZCARD"
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string(6) "ZRANGE"
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string(14) "ZREVRANGEBYLEX"
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string(13) "ZRANGEBYSCORE"
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string(5) "ZRANK"
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string(4) "ZREM"
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string(14) "ZREMRANGEBYLEX"
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string(16) "ZREMRANGEBYSCORE"
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string(9) "ZREVRANGE"
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string(16) "ZREVRANGEBYSCORE"
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string(8) "ZREVRANK"
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string(6) "ZSCORE"
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string(11) "ZUNIONSTORE"
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string(4) "SCAN"
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string(5) "SSCAN"
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string(5) "HSCAN"
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string(5) "ZSCAN"
}
["_socket":"yii\redis\Connection":private]=>
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array(0) {
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}
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object(app\components\CountryUrlRule)#52 (0) {
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object(app\components\CityUrlRule)#53 (0) {
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object(app\components\DiseaseUrlRule)#54 (0) {
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NULL
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NULL
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["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["speciality_id"]=>
object(yii\db\mysql\ColumnSchema)#248 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(13) "speciality_id"
["allowNull"]=>
bool(true)
["type"]=>
string(7) "integer"
["phpType"]=>
string(7) "integer"
["dbType"]=>
string(7) "int(11)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(11)
["precision"]=>
int(11)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["image"]=>
object(yii\db\mysql\ColumnSchema)#249 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(5) "image"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(12) "varchar(255)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(255)
["precision"]=>
int(255)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
}
}
}
}
["_builder":"yii\db\Schema":private]=>
object(yii\db\mysql\QueryBuilder)#67 (6) {
["typeMap"]=>
array(22) {
["pk"]=>
string(43) "int(11) NOT NULL AUTO_INCREMENT PRIMARY KEY"
["upk"]=>
string(52) "int(10) UNSIGNED NOT NULL AUTO_INCREMENT PRIMARY KEY"
["bigpk"]=>
string(46) "bigint(20) NOT NULL AUTO_INCREMENT PRIMARY KEY"
["ubigpk"]=>
string(55) "bigint(20) UNSIGNED NOT NULL AUTO_INCREMENT PRIMARY KEY"
["char"]=>
string(7) "char(1)"
["string"]=>
string(12) "varchar(255)"
["text"]=>
string(4) "text"
["tinyint"]=>
string(10) "tinyint(3)"
["smallint"]=>
string(11) "smallint(6)"
["integer"]=>
string(7) "int(11)"
["bigint"]=>
string(10) "bigint(20)"
["float"]=>
string(5) "float"
["double"]=>
string(6) "double"
["decimal"]=>
string(13) "decimal(10,0)"
["datetime"]=>
string(8) "datetime"
["timestamp"]=>
string(9) "timestamp"
["time"]=>
string(4) "time"
["date"]=>
string(4) "date"
["binary"]=>
string(4) "blob"
["boolean"]=>
string(10) "tinyint(1)"
["money"]=>
string(13) "decimal(19,4)"
["json"]=>
string(4) "json"
}
["db"]=>
*RECURSION*
["separator"]=>
string(1) " "
["conditionBuilders":protected]=>
array(0) {
}
["conditionClasses":protected]=>
array(13) {
["NOT"]=>
string(30) "yii\db\conditions\NotCondition"
["AND"]=>
string(30) "yii\db\conditions\AndCondition"
["OR"]=>
string(29) "yii\db\conditions\OrCondition"
["BETWEEN"]=>
string(34) "yii\db\conditions\BetweenCondition"
["NOT BETWEEN"]=>
string(34) "yii\db\conditions\BetweenCondition"
["IN"]=>
string(29) "yii\db\conditions\InCondition"
["NOT IN"]=>
string(29) "yii\db\conditions\InCondition"
["LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["NOT LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["OR LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["OR NOT LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["EXISTS"]=>
string(33) "yii\db\conditions\ExistsCondition"
["NOT EXISTS"]=>
string(33) "yii\db\conditions\ExistsCondition"
}
["expressionBuilders":protected]=>
array(15) {
["yii\db\Query"]=>
string(29) "yii\db\QueryExpressionBuilder"
["yii\db\PdoValue"]=>
string(22) "yii\db\PdoValueBuilder"
["yii\db\Expression"]=>
string(24) "yii\db\ExpressionBuilder"
["yii\db\conditions\ConjunctionCondition"]=>
string(45) "yii\db\conditions\ConjunctionConditionBuilder"
["yii\db\conditions\NotCondition"]=>
string(37) "yii\db\conditions\NotConditionBuilder"
["yii\db\conditions\AndCondition"]=>
object(yii\db\conditions\ConjunctionConditionBuilder)#142 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\OrCondition"]=>
string(45) "yii\db\conditions\ConjunctionConditionBuilder"
["yii\db\conditions\BetweenCondition"]=>
string(41) "yii\db\conditions\BetweenConditionBuilder"
["yii\db\conditions\InCondition"]=>
object(yii\db\conditions\InConditionBuilder)#114 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\LikeCondition"]=>
string(38) "yii\db\conditions\LikeConditionBuilder"
["yii\db\conditions\ExistsCondition"]=>
string(40) "yii\db\conditions\ExistsConditionBuilder"
["yii\db\conditions\SimpleCondition"]=>
string(40) "yii\db\conditions\SimpleConditionBuilder"
["yii\db\conditions\HashCondition"]=>
object(yii\db\conditions\HashConditionBuilder)#71 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\BetweenColumnsCondition"]=>
string(48) "yii\db\conditions\BetweenColumnsConditionBuilder"
["yii\db\JsonExpression"]=>
string(34) "yii\db\mysql\JsonExpressionBuilder"
}
}
["_serverVersion":"yii\db\Schema":private]=>
NULL
}
["_driverName":"yii\db\Connection":private]=>
string(5) "mysql"
["_master":"yii\db\Connection":private]=>
bool(false)
["_slave":"yii\db\Connection":private]=>
NULL
["_queryCacheInfo":"yii\db\Connection":private]=>
array(0) {
}
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
array(0) {
}
}
["i18n"]=>
object(yii\i18n\I18N)#102 (5) {
["translations"]=>
array(4) {
["app*"]=>
object(app\components\CustomMessageSource)#104 (8) {
["basePath"]=>
string(13) "@app/messages"
["fileMap"]=>
NULL
["forceTranslation"]=>
bool(false)
["sourceLanguage"]=>
string(2) "ru"
["_messages":"yii\i18n\MessageSource":private]=>
array(0) {
}
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
NULL
}
["seo*"]=>
array(1) {
["class"]=>
string(34) "app\components\CustomMessageSource"
}
["yii"]=>
object(yii\i18n\PhpMessageSource)#109 (8) {
["basePath"]=>
string(13) "@yii/messages"
["fileMap"]=>
NULL
["forceTranslation"]=>
bool(false)
["sourceLanguage"]=>
string(5) "en-US"
["_messages":"yii\i18n\MessageSource":private]=>
array(1) {
["ru/yii"]=>
array(118) {
[""{attribute}" does not support operator "{operator}"."]=>
string(74) ""{attribute}" не поддерживает оператор "{operator}"."
["Condition for "{attribute}" should be either a value or valid operator specification."]=>
string(150) "Условие для "{attribute}" должно быть или значением или верной спецификацией оператора."
["Operator "{operator}" must be used with a search attribute."]=>
string(111) "Оператор "{operator}" должен использоваться через атрибут поиска."
["Operator "{operator}" requires multiple operands."]=>
string(83) "Оператор "{operator}" требует несколько операндов."
["The format of {filter} is invalid."]=>
string(53) "Формат фильтра {filter} не верен."
["Unknown filter attribute "{attribute}""]=>
string(66) "Неизвестный атрибут фильтра "{attribute}""
[" and "]=>
string(4) " и "
["(not set)"]=>
string(19) "(не задано)"
["An internal server error occurred."]=>
string(66) "Возникла внутренняя ошибка сервера."
["Are you sure you want to delete this item?"]=>
string(80) "Вы уверены, что хотите удалить этот элемент?"
["Delete"]=>
string(14) "Удалить"
["Error"]=>
string(12) "Ошибка"
["File upload failed."]=>
string(48) "Загрузка файла не удалась."
["Home"]=>
string(14) "Главная"
["Invalid data received for parameter "{param}"."]=>
string(71) "Неправильное значение параметра "{param}"."
["Login Required"]=>
string(28) "Требуется вход."
["Missing required arguments: {params}"]=>
string(76) "Отсутствуют обязательные аргументы: {params}"
["Missing required parameters: {params}"]=>
string(76) "Отсутствуют обязательные параметры: {params}"
["No"]=>
string(6) "Нет"
["No results found."]=>
string(33) "Ничего не найдено."
["Only files with these MIME types are allowed: {mimeTypes}."]=>
string(119) "Разрешена загрузка файлов только со следующими MIME-типами: {mimeTypes}."
["Only files with these extensions are allowed: {extensions}."]=>
string(127) "Разрешена загрузка файлов только со следующими расширениями: {extensions}."
["Page not found."]=>
string(37) "Страница не найдена."
["Please fix the following errors:"]=>
string(51) "Исправьте следующие ошибки:"
["Please upload a file."]=>
string(28) "Загрузите файл."
["Powered by {yii}"]=>
string(27) "Работает на {yii}"
["Showing {begin, number}-{end, number} of {totalCount, number} {totalCount, plural, one{item} other{items}}."]=>
string(100) "Показаны записи {begin, number}-{end, number} из {totalCount, number} ."
["The combination {values} of {attributes} has already been taken."]=>
string(92) "Комбинация {values} параметров {attributes} уже существует."
["The file "{file}" is not an image."]=>
string(67) "Файл «{file}» не является изображением."
["The file "{file}" is too big. Its size cannot exceed {formattedLimit}."]=>
string(118) "Файл «{file}» слишком большой. Размер не должен превышать {formattedLimit}."
["The file "{file}" is too small. Its size cannot be smaller than {formattedLimit}."]=>
string(118) "Файл «{file}» слишком маленький. Размер должен быть более {formattedLimit}."
["The format of {attribute} is invalid."]=>
string(63) "Неверный формат значения «{attribute}»."
["The image "{file}" is too large. The height cannot be larger than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком большой. Высота не должна превышать {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too large. The width cannot be larger than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком большой. Ширина не должна превышать {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too small. The height cannot be smaller than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком маленький. Высота должна быть более {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too small. The width cannot be smaller than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком маленький. Ширина должна быть более {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The requested view "{name}" was not found."]=>
string(90) "Запрашиваемый файл представления "{name}" не найден."
["The verification code is incorrect."]=>
string(55) "Неправильный проверочный код."
["Total {count, number} {count, plural, one{item} other{items}}."]=>
string(128) "Всего {count, number} {count, plural, one{запись} few{записи} many{записей} other{записи}}."
["Unable to verify your data submission."]=>
string(73) "Не удалось проверить переданные данные."
["Unknown alias: -{name}"]=>
string(50) "Неизвестный псевдоним: -{name}"
["Unknown option: --{name}"]=>
string(43) "Неизвестная опция: --{name}"
["Update"]=>
string(26) "Редактировать"
["View"]=>
string(16) "Просмотр"
["Yes"]=>
string(4) "Да"
["Yii Framework"]=>
string(13) "Yii Framework"
["You are not allowed to perform this action."]=>
string(84) "Вам не разрешено производить данное действие."
["You can upload at most {limit, number} {limit, plural, one{file} other{files}}."]=>
string(157) "Вы не можете загружать более {limit, number} {limit, plural, one{файла} few{файлов} many{файлов} other{файла}}."
["in {delta, plural, =1{a day} other{# days}}"]=>
string(103) "через {delta, plural, =1{день} one{# день} few{# дня} many{# дней} other{# дня}}"
["in {delta, plural, =1{a minute} other{# minutes}}"]=>
string(125) "через {delta, plural, =1{минуту} one{# минуту} few{# минуты} many{# минут} other{# минуты}}"
["in {delta, plural, =1{a month} other{# months}}"]=>
string(125) "через {delta, plural, =1{месяц} one{# месяц} few{# месяца} many{# месяцев} other{# месяца}}"
["in {delta, plural, =1{a second} other{# seconds}}"]=>
string(135) "через {delta, plural, =1{секунду} one{# секунду} few{# секунды} many{# секунд} other{# секунды}}"
["in {delta, plural, =1{a year} other{# years}}"]=>
string(101) "через {delta, plural, =1{год} one{# год} few{# года} many{# лет} other{# года}}"
["in {delta, plural, =1{an hour} other{# hours}}"]=>
string(105) "через {delta, plural, =1{час} one{# час} few{# часа} many{# часов} other{# часа}}"
["just now"]=>
string(23) "прямо сейчас"
["the input value"]=>
string(35) "введённое значение"
["{attribute} "{value}" has already been taken."]=>
string(72) "Значение «{value}» для «{attribute}» уже занято."
["{attribute} cannot be blank."]=>
string(56) "Необходимо заполнить «{attribute}»."
["{attribute} contains wrong subnet mask."]=>
string(93) "Значение «{attribute}» содержит неверную маску подсети."
["{attribute} is invalid."]=>
string(48) "Значение «{attribute}» неверно."
["{attribute} is not a valid URL."]=>
string(80) "Значение «{attribute}» не является правильным URL."
["{attribute} is not a valid email address."]=>
string(97) "Значение «{attribute}» не является правильным email адресом."
["{attribute} is not in the allowed range."]=>
string(126) "Значение «{attribute}» не входит в список разрешенных диапазонов адресов."
["{attribute} must be "{requiredValue}"."]=>
string(86) "Значение «{attribute}» должно быть равно «{requiredValue}»."
["{attribute} must be a number."]=>
string(68) "Значение «{attribute}» должно быть числом."
["{attribute} must be a string."]=>
string(70) "Значение «{attribute}» должно быть строкой."
["{attribute} must be a valid IP address."]=>
string(94) "Значение «{attribute}» должно быть правильным IP адресом."
["{attribute} must be an IP address with specified subnet."]=>
string(93) "Значение «{attribute}» должно быть IP адресом с подсетью."
["{attribute} must be an integer."]=>
string(79) "Значение «{attribute}» должно быть целым числом."
["{attribute} must be either "{true}" or "{false}"."]=>
string(96) "Значение «{attribute}» должно быть равно «{true}» или «{false}»."
["{attribute} must be equal to "{compareValueOrAttribute}"."]=>
string(96) "Значение «{attribute}» должно быть равно «{compareValueOrAttribute}»."
["{attribute} must be greater than "{compareValueOrAttribute}"."]=>
string(115) "Значение «{attribute}» должно быть больше значения «{compareValueOrAttribute}»."
["{attribute} must be greater than or equal to "{compareValueOrAttribute}"."]=>
string(133) "Значение «{attribute}» должно быть больше или равно значения «{compareValueOrAttribute}»."
["{attribute} must be less than "{compareValueOrAttribute}"."]=>
string(115) "Значение «{attribute}» должно быть меньше значения «{compareValueOrAttribute}»."
["{attribute} must be less than or equal to "{compareValueOrAttribute}"."]=>
string(133) "Значение «{attribute}» должно быть меньше или равно значения «{compareValueOrAttribute}»."
["{attribute} must be no greater than {max}."]=>
string(76) "Значение «{attribute}» не должно превышать {max}."
["{attribute} must be no less than {min}."]=>
string(79) "Значение «{attribute}» должно быть не меньше {min}."
["{attribute} must not be a subnet."]=>
string(77) "Значение «{attribute}» не должно быть подсетью."
["{attribute} must not be an IPv4 address."]=>
string(80) "Значение «{attribute}» не должно быть IPv4 адресом."
["{attribute} must not be an IPv6 address."]=>
string(80) "Значение «{attribute}» не должно быть IPv6 адресом."
["{attribute} must not be equal to "{compareValueOrAttribute}"."]=>
string(101) "Значение «{attribute}» не должно быть равно «{compareValueOrAttribute}»."
["{attribute} should contain at least {min, number} {min, plural, one{character} other{characters}}."]=>
string(192) "Значение «{attribute}» должно содержать минимум {min, number} {min, plural, one{символ} few{символа} many{символов} other{символа}}."
["{attribute} should contain at most {max, number} {max, plural, one{character} other{characters}}."]=>
string(194) "Значение «{attribute}» должно содержать максимум {max, number} {max, plural, one{символ} few{символа} many{символов} other{символа}}."
["{attribute} should contain {length, number} {length, plural, one{character} other{characters}}."]=>
string(183) "Значение «{attribute}» должно содержать {length, number} {length, plural, one{символ} few{символа} many{символов} other{символа}}."
["{delta, plural, =1{1 day} other{# days}}"]=>
string(79) "{delta, plural, one{# день} few{# дня} many{# дней} other{# дня}}"
["{delta, plural, =1{1 hour} other{# hours}}"]=>
string(83) "{delta, plural, one{# час} few{# часа} many{# часов} other{# часа}}"
["{delta, plural, =1{1 minute} other{# minutes}}"]=>
string(97) "{delta, plural, one{# минута} few{# минуты} many{# минут} other{# минуты}}"
["{delta, plural, =1{1 month} other{# months}}"]=>
string(99) "{delta, plural, one{# месяц} few{# месяца} many{# месяцев} other{# месяца}}"
["{delta, plural, =1{1 second} other{# seconds}}"]=>
string(105) "{delta, plural, one{# секунда} few{# секунды} many{# секунд} other{# секунды}}"
["{delta, plural, =1{1 year} other{# years}}"]=>
string(79) "{delta, plural, one{# год} few{# года} many{# лет} other{# года}}"
["{delta, plural, =1{a day} other{# days}} ago"]=>
string(103) "{delta, plural, =1{день} one{# день} few{# дня} many{# дней} other{# дня}} назад"
["{delta, plural, =1{a minute} other{# minutes}} ago"]=>
string(125) "{delta, plural, =1{минуту} one{# минуту} few{# минуты} many{# минут} other{# минуты}} назад"
["{delta, plural, =1{a month} other{# months}} ago"]=>
string(125) "{delta, plural, =1{месяц} one{# месяц} few{# месяца} many{# месяцев} other{# месяца}} назад"
["{delta, plural, =1{a second} other{# seconds}} ago"]=>
string(135) "{delta, plural, =1{секунду} one{# секунду} few{# секунды} many{# секунд} other{# секунды}} назад"
["{delta, plural, =1{a year} other{# years}} ago"]=>
string(101) "{delta, plural, =1{год} one{# год} few{# года} many{# лет} other{# года}} назад"
["{delta, plural, =1{an hour} other{# hours}} ago"]=>
string(105) "{delta, plural, =1{час} one{# час} few{# часа} many{# часов} other{# часа}} назад"
["{nFormatted} B"]=>
string(15) "{nFormatted} Б"
["{nFormatted} GB"]=>
string(17) "{nFormatted} ГБ"
["{nFormatted} GiB"]=>
string(19) "{nFormatted} ГиБ"
["{nFormatted} KB"]=>
string(17) "{nFormatted} КБ"
["{nFormatted} KiB"]=>
string(19) "{nFormatted} КиБ"
["{nFormatted} MB"]=>
string(17) "{nFormatted} МБ"
["{nFormatted} MiB"]=>
string(19) "{nFormatted} МиБ"
["{nFormatted} PB"]=>
string(17) "{nFormatted} ПБ"
["{nFormatted} PiB"]=>
string(19) "{nFormatted} ПиБ"
["{nFormatted} TB"]=>
string(17) "{nFormatted} ТБ"
["{nFormatted} TiB"]=>
string(19) "{nFormatted} ТиБ"
["{nFormatted} {n, plural, =1{byte} other{bytes}}"]=>
string(92) "{nFormatted} {n, plural, one{байт} few{байта} many{байтов} other{байта}}"
["{nFormatted} {n, plural, =1{gibibyte} other{gibibytes}}"]=>
string(124) "{nFormatted} {n, plural, one{гибибайт} few{гибибайта} many{гибибайтов} other{гибибайта}}"
["{nFormatted} {n, plural, =1{gigabyte} other{gigabytes}}"]=>
string(124) "{nFormatted} {n, plural, one{гигабайт} few{гигабайта} many{гигабайтов} other{гигабайта}}"
["{nFormatted} {n, plural, =1{kibibyte} other{kibibytes}}"]=>
string(124) "{nFormatted} {n, plural, one{кибибайт} few{кибибайта} many{кибибайтов} other{кибибайта}}"
["{nFormatted} {n, plural, =1{kilobyte} other{kilobytes}}"]=>
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для которого набираются группы пациентов с разными формами онкологических заболеваний:
Метастатический HR+ и HER2+ рак молочной железы, Метастатический HR+ и HER2- рак молочной железы, Немелкоклеточный рак легкого Меланома при показаниях к хирургическому удалению метастазов в головном мозге Меланома при наличии лептоменингеальные метастазов Принцип действия Абемациклиба
Абемациклиб блокирует ферменты CDK4 и CDK6, которые играют важную роль в делении злокачественных клеток. В результате, рост опухоли прекращается, а ее ткани разрушаются. Предполагается, что препарат станет высокоэффективным средством в лечении рака молочной железы , немелкоклеточного рака легкого и меланомы , в том числе с метастазами.
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Возраст старше 18 лет; Отсутствие беременности или планов на зачатие в последующие за лечением 3 месяца, также не допускаются женщины, кормящие грудью; Наличие диагностированного и подтвержденного онкологического заболевания, входящего в перечень выбранных для исследования; Отсутствие сердечно-сосудистых и инфекционных заболеваний. Ход исследования
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Организация участия в исследовании
На сайте DocLand. ru
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Организация участия в исследовании
На сайте DocLand. ru
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}
["beforeInsert"]=>
array(1) {
[0]=>
array(2) {
[0]=>
array(2) {
[0]=>
object(yii\behaviors\TimestampBehavior)#78 (7) {
["createdAtAttribute"]=>
string(10) "created_at"
["updatedAtAttribute"]=>
string(10) "updated_at"
["value"]=>
object(Closure)#73 (1) {
["this"]=>
*RECURSION*
}
["attributes"]=>
array(2) {
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array(2) {
[0]=>
string(10) "created_at"
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string(10) "updated_at"
}
["beforeUpdate"]=>
string(10) "updated_at"
}
["skipUpdateOnClean"]=>
bool(true)
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bool(false)
["owner"]=>
*RECURSION*
}
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string(18) "evaluateAttributes"
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[1]=>
NULL
}
}
["beforeUpdate"]=>
array(1) {
[0]=>
array(2) {
[0]=>
array(2) {
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object(yii\behaviors\TimestampBehavior)#78 (7) {
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string(10) "created_at"
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string(10) "updated_at"
["value"]=>
object(Closure)#73 (1) {
["this"]=>
*RECURSION*
}
["attributes"]=>
array(2) {
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array(2) {
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string(10) "created_at"
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string(10) "updated_at"
}
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string(10) "updated_at"
}
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bool(true)
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bool(false)
["owner"]=>
*RECURSION*
}
[1]=>
string(18) "evaluateAttributes"
}
[1]=>
NULL
}
}
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
array(2) {
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object(app\components\MultilingualBehavior)#76 (12) {
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array(9) {
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string(4) "name"
[1]=>
string(12) "rewrite_name"
[2]=>
string(6) "source"
[3]=>
string(8) "announce"
[4]=>
string(4) "text"
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string(6) "seo_h1"
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string(9) "seo_title"
[7]=>
string(12) "seo_keywords"
[8]=>
string(15) "seo_description"
}
["languages"]=>
array(1) {
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string(2) "en"
}
["defaultLanguage"]=>
string(2) "ru"
["tableName"]=>
string(9) "lang_post"
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string(19) "app\models\PostLang"
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string(4) "Lang"
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string(7) "post_id"
["languageField"]=>
string(8) "language"
["forceDelete"]=>
bool(true)
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string(2) "ru"
["langAttributes":"app\components\MultilingualBehavior":private]=>
array(0) {
}
["owner"]=>
*RECURSION*
}
[1]=>
object(yii\behaviors\TimestampBehavior)#78 (7) {
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string(10) "created_at"
["updatedAtAttribute"]=>
string(10) "updated_at"
["value"]=>
object(Closure)#73 (1) {
["this"]=>
*RECURSION*
}
["attributes"]=>
array(2) {
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array(2) {
[0]=>
string(10) "created_at"
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string(10) "updated_at"
}
["beforeUpdate"]=>
string(10) "updated_at"
}
["skipUpdateOnClean"]=>
bool(true)
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bool(false)
["owner"]=>
*RECURSION*
}
}
}
}
["bindParams":protected]=>
array(0) {
}
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
NULL
}
}
[1]=>
NULL
}
}
["endPage"]=>
array(1) {
[0]=>
array(2) {
[0]=>
object(Closure)#22 (2) {
["this"]=>
object(app\components\AssetsAutoCompress)#23 (12) {
["enabled"]=>
bool(true)
["jsCompress"]=>
bool(false)
["jsCompressFlaggedComments"]=>
bool(true)
["cssCompress"]=>
bool(true)
["cssFileCompile"]=>
bool(true)
["cssFileCompress"]=>
bool(false)
["cssFileBottom"]=>
bool(false)
["jsFileCompile"]=>
bool(false)
["jsFileCompress"]=>
bool(true)
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
NULL
}
["parameter"]=>
array(1) {
["$e"]=>
string(10) ""
}
}
[1]=>
NULL
}
}
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
array(0) {
}
}
