Нобелевскую премию по медицине присудили за достижения в борьбе с раком
Нобелевскую премию в области медицины и физиологии в этом году присудили американцу Джеймсу Эллисону и японцу Тасуку Хондзё, открытия которых легли в основу нового подхода в лечении рака , в корне отличающегося от применяемых сегодня химио - и радиотерапии . Ученые выяснили, как помешать клеткам злокачественной опухоли блокировать действия иммунной системы по их уничтожению.
Иммунная система человека нацелена на обнаружение и разрушение патологически измененных клеток. Однако клетки рака нашли способ обойти естественную защиту организма, благодаря чему имеют возможность беспрепятственно делиться и размножаться. Делают они это, используя так называемые контрольные точки иммунного ответа – молекулы, которые блокируют иммунитет, не позволяя ему атаковать дефектные ткани.
В 1992 году Тасуку Хондзё из Киото обнаружил на поверхности Т-лимфоцитов, клеток иммунной системы, молекулу белка PD-1, отвечающего за механизм запрограммированной смерти клеток. Именно его блокируют клетки опухоли, делаясь невидимыми для иммунитета. Несколькими годами позже уроженец Техаса Джеймс Эллисон, независимо от своего японского коллеги, открыл другой белковый рецептор, который функционирует как иммунная контрольная точка, подавляя ответ иммунной системы. Позже вместе со своей командой он разработал терапевтические антитела, которые не позволяют раку «отключать» PD-1 и подобные ему белки, вернув тем самым организму способность распознавать и убивать клетки опухоли.
Открытие ученых легло в основу нового класса противораковых препаратов, ингибирующих иммунные контрольные точки, которые в настоящее время успешно используются в лечении пациентов с агрессивной меланомой, раком легких, почек, лейкозом и другими видами онкологии. Многим из них новое лекарство помогло спасти или значительно продлить жизнь.
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Иммунная система человека нацелена на обнаружение и разрушение патологически измененных клеток. Однако клетки рака нашли способ обойти естественную защиту организма, благодаря чему имеют возможность беспрепятственно делиться и размножаться. Делают они это, используя так называемые контрольные точки иммунного ответа – молекулы, которые блокируют иммунитет, не позволяя ему атаковать дефектные ткани.
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Иммунная система человека нацелена на обнаружение и разрушение патологически измененных клеток. Однако клетки рака нашли способ обойти естественную защиту организма, благодаря чему имеют возможность беспрепятственно делиться и размножаться. Делают они это, используя так называемые контрольные точки иммунного ответа – молекулы, которые блокируют иммунитет, не позволяя ему атаковать дефектные ткани.
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string(10) "//"
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string(113) "#^site/(?P(login|logout|change-email|change-password|error|prices|about|contacts|register-partner))$#u"
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object(yii\web\UrlRule)#35 (16) {
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NULL
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string(8) "//"
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NULL
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array(1) {
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string(35) "#^privacy\-policy|terms\-of\-use$#u"
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array(0) {
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object(yii\web\UrlRule)#36 (16) {
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NULL
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string(23) "///"
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string(55) "#^(?Ppartner)/(?P[^\/]+)/index$#u"
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
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array(2) {
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object(yii\web\UrlRule)#37 (16) {
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NULL
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string(30) "//"
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string(6) "action"
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["_template":"yii\web\UrlRule":private]=>
string(32) "////"
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string(71) "#^(?Ppartner)/(?P[^\/]+)/(?P[^\/]+)$#u"
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array(0) {
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array(3) {
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string(8) ""
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object(yii\web\UrlRule)#38 (16) {
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NULL
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array(0) {
}
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NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
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["_template":"yii\web\UrlRule":private]=>
string(11) "/countries/"
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NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[9]=>
object(yii\web\UrlRule)#39 (16) {
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string(7) "clinics"
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string(12) "#^clinics$#u"
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NULL
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string(12) "search/index"
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array(0) {
}
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NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
}
["_template":"yii\web\UrlRule":private]=>
string(9) "/clinics/"
["_routeRule":"yii\web\UrlRule":private]=>
NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[10]=>
object(yii\web\UrlRule)#40 (16) {
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string(9) "illnesses"
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string(14) "#^illnesses$#u"
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NULL
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array(0) {
}
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NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
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["_template":"yii\web\UrlRule":private]=>
string(11) "/illnesses/"
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NULL
["_paramRules":"yii\web\UrlRule":private]=>
array(0) {
}
["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
[11]=>
object(yii\web\UrlRule)#41 (16) {
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string(12) "certificates"
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string(17) "#^certificates$#u"
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NULL
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string(17) "certificate/index"
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array(0) {
}
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NULL
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NULL
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NULL
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bool(true)
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NULL
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int(2)
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array(0) {
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["_template":"yii\web\UrlRule":private]=>
string(14) "/certificates/"
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NULL
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array(0) {
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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}
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object(yii\web\UrlRule)#42 (16) {
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string(19) "certificates/[^\/]+)$#u"
["host"]=>
NULL
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string(16) "certificate/view"
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array(0) {
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NULL
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bool(true)
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["_template":"yii\web\UrlRule":private]=>
string(21) "/certificates/"
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string(41) "#^blog/tags/(?P[a-z0-9\-]+)$#u"
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NULL
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string(28) "/blog/tags//"
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NULL
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array(1) {
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["_routeParams":"yii\web\UrlRule":private]=>
array(0) {
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[14]=>
object(yii\web\UrlRule)#44 (16) {
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string(9) "blog/tags"
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string(14) "#^blog/tags$#u"
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NULL
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array(0) {
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array(0) {
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[15]=>
object(yii\web\UrlRule)#45 (16) {
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NULL
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array(1) {
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array(0) {
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object(yii\web\UrlRule)#46 (16) {
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array(0) {
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array(3) {
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array(0) {
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object(yii\web\UrlRule)#49 (16) {
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object(app\components\DoctorUrlRule)#50 (0) {
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object(app\components\SpecialityUrlRule)#51 (0) {
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object(app\components\CountryUrlRule)#52 (0) {
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object(app\components\CityUrlRule)#53 (0) {
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object(app\components\DiseaseUrlRule)#54 (0) {
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object(app\components\BranchUrlRule)#55 (0) {
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object(app\components\ClinicUrlRule)#56 (0) {
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string(8) "SHUTDOWN"
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string(6) "SINTER"
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string(11) "SINTERSTORE"
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string(9) "SISMEMBER"
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string(7) "SLAVEOF"
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string(7) "SLOWLOG"
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string(8) "SMEMBERS"
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string(5) "SMOVE"
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string(4) "SORT"
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string(4) "SPOP"
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string(11) "SRANDMEMBER"
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string(4) "SREM"
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string(6) "STRLEN"
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string(9) "SUBSCRIBE"
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string(6) "SUNION"
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string(11) "SUNIONSTORE"
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string(6) "SWAPDB"
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string(4) "SYNC"
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string(4) "TIME"
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string(5) "TOUCH"
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string(3) "TTL"
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string(4) "TYPE"
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string(11) "UNSUBSCRIBE"
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string(6) "UNLINK"
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string(7) "UNWATCH"
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string(4) "WAIT"
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string(5) "WATCH"
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string(4) "ZADD"
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string(5) "ZCARD"
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string(6) "ZCOUNT"
[177]=>
string(7) "ZINCRBY"
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string(11) "ZINTERSTORE"
[179]=>
string(9) "ZLEXCOUNT"
[180]=>
string(6) "ZRANGE"
[181]=>
string(11) "ZRANGEBYLEX"
[182]=>
string(14) "ZREVRANGEBYLEX"
[183]=>
string(13) "ZRANGEBYSCORE"
[184]=>
string(5) "ZRANK"
[185]=>
string(4) "ZREM"
[186]=>
string(14) "ZREMRANGEBYLEX"
[187]=>
string(15) "ZREMRANGEBYRANK"
[188]=>
string(16) "ZREMRANGEBYSCORE"
[189]=>
string(9) "ZREVRANGE"
[190]=>
string(16) "ZREVRANGEBYSCORE"
[191]=>
string(8) "ZREVRANK"
[192]=>
string(6) "ZSCORE"
[193]=>
string(11) "ZUNIONSTORE"
[194]=>
string(4) "SCAN"
[195]=>
string(5) "SSCAN"
[196]=>
string(5) "HSCAN"
[197]=>
string(5) "ZSCAN"
}
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resource(55) of type (stream)
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NULL
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NULL
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array(1) {
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array(0) {
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object(app\components\CountryUrlRule)#52 (0) {
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object(app\components\CityUrlRule)#53 (0) {
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object(app\components\DiseaseUrlRule)#54 (0) {
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object(app\components\DiseaseUrlRule)#54 (0) {
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object(app\components\BranchUrlRule)#55 (0) {
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object(yii\db\Expression)#227 (2) {
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string(17) "CURRENT_TIMESTAMP"
["params"]=>
array(0) {
}
}
["enumValues"]=>
NULL
["size"]=>
NULL
["precision"]=>
NULL
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["seo_title"]=>
object(yii\db\mysql\ColumnSchema)#228 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(9) "seo_title"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(12) "varchar(255)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(255)
["precision"]=>
int(255)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["seo_h1"]=>
object(yii\db\mysql\ColumnSchema)#229 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(6) "seo_h1"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(12) "varchar(255)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(255)
["precision"]=>
int(255)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["seo_description"]=>
object(yii\db\mysql\ColumnSchema)#230 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(15) "seo_description"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(13) "varchar(1024)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(1024)
["precision"]=>
int(1024)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["seo_keywords"]=>
object(yii\db\mysql\ColumnSchema)#231 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(12) "seo_keywords"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(13) "varchar(1024)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(1024)
["precision"]=>
int(1024)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["is_disease"]=>
object(yii\db\mysql\ColumnSchema)#232 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(10) "is_disease"
["allowNull"]=>
bool(true)
["type"]=>
string(7) "tinyint"
["phpType"]=>
string(7) "integer"
["dbType"]=>
string(10) "tinyint(1)"
["defaultValue"]=>
int(1)
["enumValues"]=>
NULL
["size"]=>
int(1)
["precision"]=>
int(1)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["speciality_id"]=>
object(yii\db\mysql\ColumnSchema)#233 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(13) "speciality_id"
["allowNull"]=>
bool(true)
["type"]=>
string(7) "integer"
["phpType"]=>
string(7) "integer"
["dbType"]=>
string(7) "int(11)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(11)
["precision"]=>
int(11)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
["image"]=>
object(yii\db\mysql\ColumnSchema)#234 (15) {
["disableJsonSupport"]=>
bool(false)
["name"]=>
string(5) "image"
["allowNull"]=>
bool(true)
["type"]=>
string(6) "string"
["phpType"]=>
string(6) "string"
["dbType"]=>
string(12) "varchar(255)"
["defaultValue"]=>
NULL
["enumValues"]=>
NULL
["size"]=>
int(255)
["precision"]=>
int(255)
["scale"]=>
NULL
["isPrimaryKey"]=>
bool(false)
["autoIncrement"]=>
bool(false)
["unsigned"]=>
bool(false)
["comment"]=>
string(0) ""
}
}
}
}
}
["_builder":"yii\db\Schema":private]=>
object(yii\db\mysql\QueryBuilder)#67 (6) {
["typeMap"]=>
array(22) {
["pk"]=>
string(43) "int(11) NOT NULL AUTO_INCREMENT PRIMARY KEY"
["upk"]=>
string(52) "int(10) UNSIGNED NOT NULL AUTO_INCREMENT PRIMARY KEY"
["bigpk"]=>
string(46) "bigint(20) NOT NULL AUTO_INCREMENT PRIMARY KEY"
["ubigpk"]=>
string(55) "bigint(20) UNSIGNED NOT NULL AUTO_INCREMENT PRIMARY KEY"
["char"]=>
string(7) "char(1)"
["string"]=>
string(12) "varchar(255)"
["text"]=>
string(4) "text"
["tinyint"]=>
string(10) "tinyint(3)"
["smallint"]=>
string(11) "smallint(6)"
["integer"]=>
string(7) "int(11)"
["bigint"]=>
string(10) "bigint(20)"
["float"]=>
string(5) "float"
["double"]=>
string(6) "double"
["decimal"]=>
string(13) "decimal(10,0)"
["datetime"]=>
string(8) "datetime"
["timestamp"]=>
string(9) "timestamp"
["time"]=>
string(4) "time"
["date"]=>
string(4) "date"
["binary"]=>
string(4) "blob"
["boolean"]=>
string(10) "tinyint(1)"
["money"]=>
string(13) "decimal(19,4)"
["json"]=>
string(4) "json"
}
["db"]=>
*RECURSION*
["separator"]=>
string(1) " "
["conditionBuilders":protected]=>
array(0) {
}
["conditionClasses":protected]=>
array(13) {
["NOT"]=>
string(30) "yii\db\conditions\NotCondition"
["AND"]=>
string(30) "yii\db\conditions\AndCondition"
["OR"]=>
string(29) "yii\db\conditions\OrCondition"
["BETWEEN"]=>
string(34) "yii\db\conditions\BetweenCondition"
["NOT BETWEEN"]=>
string(34) "yii\db\conditions\BetweenCondition"
["IN"]=>
string(29) "yii\db\conditions\InCondition"
["NOT IN"]=>
string(29) "yii\db\conditions\InCondition"
["LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["NOT LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["OR LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["OR NOT LIKE"]=>
string(31) "yii\db\conditions\LikeCondition"
["EXISTS"]=>
string(33) "yii\db\conditions\ExistsCondition"
["NOT EXISTS"]=>
string(33) "yii\db\conditions\ExistsCondition"
}
["expressionBuilders":protected]=>
array(15) {
["yii\db\Query"]=>
string(29) "yii\db\QueryExpressionBuilder"
["yii\db\PdoValue"]=>
string(22) "yii\db\PdoValueBuilder"
["yii\db\Expression"]=>
string(24) "yii\db\ExpressionBuilder"
["yii\db\conditions\ConjunctionCondition"]=>
string(45) "yii\db\conditions\ConjunctionConditionBuilder"
["yii\db\conditions\NotCondition"]=>
string(37) "yii\db\conditions\NotConditionBuilder"
["yii\db\conditions\AndCondition"]=>
object(yii\db\conditions\ConjunctionConditionBuilder)#127 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\OrCondition"]=>
string(45) "yii\db\conditions\ConjunctionConditionBuilder"
["yii\db\conditions\BetweenCondition"]=>
string(41) "yii\db\conditions\BetweenConditionBuilder"
["yii\db\conditions\InCondition"]=>
object(yii\db\conditions\InConditionBuilder)#114 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\LikeCondition"]=>
string(38) "yii\db\conditions\LikeConditionBuilder"
["yii\db\conditions\ExistsCondition"]=>
string(40) "yii\db\conditions\ExistsConditionBuilder"
["yii\db\conditions\SimpleCondition"]=>
string(40) "yii\db\conditions\SimpleConditionBuilder"
["yii\db\conditions\HashCondition"]=>
object(yii\db\conditions\HashConditionBuilder)#71 (1) {
["queryBuilder":protected]=>
*RECURSION*
}
["yii\db\conditions\BetweenColumnsCondition"]=>
string(48) "yii\db\conditions\BetweenColumnsConditionBuilder"
["yii\db\JsonExpression"]=>
string(34) "yii\db\mysql\JsonExpressionBuilder"
}
}
["_serverVersion":"yii\db\Schema":private]=>
NULL
}
["_driverName":"yii\db\Connection":private]=>
string(5) "mysql"
["_master":"yii\db\Connection":private]=>
bool(false)
["_slave":"yii\db\Connection":private]=>
NULL
["_queryCacheInfo":"yii\db\Connection":private]=>
array(0) {
}
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
array(0) {
}
}
["i18n"]=>
object(yii\i18n\I18N)#102 (5) {
["translations"]=>
array(4) {
["app*"]=>
object(app\components\CustomMessageSource)#104 (8) {
["basePath"]=>
string(13) "@app/messages"
["fileMap"]=>
NULL
["forceTranslation"]=>
bool(false)
["sourceLanguage"]=>
string(2) "ru"
["_messages":"yii\i18n\MessageSource":private]=>
array(0) {
}
["_events":"yii\base\Component":private]=>
array(0) {
}
["_eventWildcards":"yii\base\Component":private]=>
array(0) {
}
["_behaviors":"yii\base\Component":private]=>
NULL
}
["seo*"]=>
array(1) {
["class"]=>
string(34) "app\components\CustomMessageSource"
}
["yii"]=>
object(yii\i18n\PhpMessageSource)#109 (8) {
["basePath"]=>
string(13) "@yii/messages"
["fileMap"]=>
NULL
["forceTranslation"]=>
bool(false)
["sourceLanguage"]=>
string(5) "en-US"
["_messages":"yii\i18n\MessageSource":private]=>
array(1) {
["ru/yii"]=>
array(118) {
[""{attribute}" does not support operator "{operator}"."]=>
string(74) ""{attribute}" не поддерживает оператор "{operator}"."
["Condition for "{attribute}" should be either a value or valid operator specification."]=>
string(150) "Условие для "{attribute}" должно быть или значением или верной спецификацией оператора."
["Operator "{operator}" must be used with a search attribute."]=>
string(111) "Оператор "{operator}" должен использоваться через атрибут поиска."
["Operator "{operator}" requires multiple operands."]=>
string(83) "Оператор "{operator}" требует несколько операндов."
["The format of {filter} is invalid."]=>
string(53) "Формат фильтра {filter} не верен."
["Unknown filter attribute "{attribute}""]=>
string(66) "Неизвестный атрибут фильтра "{attribute}""
[" and "]=>
string(4) " и "
["(not set)"]=>
string(19) "(не задано)"
["An internal server error occurred."]=>
string(66) "Возникла внутренняя ошибка сервера."
["Are you sure you want to delete this item?"]=>
string(80) "Вы уверены, что хотите удалить этот элемент?"
["Delete"]=>
string(14) "Удалить"
["Error"]=>
string(12) "Ошибка"
["File upload failed."]=>
string(48) "Загрузка файла не удалась."
["Home"]=>
string(14) "Главная"
["Invalid data received for parameter "{param}"."]=>
string(71) "Неправильное значение параметра "{param}"."
["Login Required"]=>
string(28) "Требуется вход."
["Missing required arguments: {params}"]=>
string(76) "Отсутствуют обязательные аргументы: {params}"
["Missing required parameters: {params}"]=>
string(76) "Отсутствуют обязательные параметры: {params}"
["No"]=>
string(6) "Нет"
["No results found."]=>
string(33) "Ничего не найдено."
["Only files with these MIME types are allowed: {mimeTypes}."]=>
string(119) "Разрешена загрузка файлов только со следующими MIME-типами: {mimeTypes}."
["Only files with these extensions are allowed: {extensions}."]=>
string(127) "Разрешена загрузка файлов только со следующими расширениями: {extensions}."
["Page not found."]=>
string(37) "Страница не найдена."
["Please fix the following errors:"]=>
string(51) "Исправьте следующие ошибки:"
["Please upload a file."]=>
string(28) "Загрузите файл."
["Powered by {yii}"]=>
string(27) "Работает на {yii}"
["Showing {begin, number}-{end, number} of {totalCount, number} {totalCount, plural, one{item} other{items}}."]=>
string(100) "Показаны записи {begin, number}-{end, number} из {totalCount, number} ."
["The combination {values} of {attributes} has already been taken."]=>
string(92) "Комбинация {values} параметров {attributes} уже существует."
["The file "{file}" is not an image."]=>
string(67) "Файл «{file}» не является изображением."
["The file "{file}" is too big. Its size cannot exceed {formattedLimit}."]=>
string(118) "Файл «{file}» слишком большой. Размер не должен превышать {formattedLimit}."
["The file "{file}" is too small. Its size cannot be smaller than {formattedLimit}."]=>
string(118) "Файл «{file}» слишком маленький. Размер должен быть более {formattedLimit}."
["The format of {attribute} is invalid."]=>
string(63) "Неверный формат значения «{attribute}»."
["The image "{file}" is too large. The height cannot be larger than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком большой. Высота не должна превышать {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too large. The width cannot be larger than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком большой. Ширина не должна превышать {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too small. The height cannot be smaller than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком маленький. Высота должна быть более {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The image "{file}" is too small. The width cannot be smaller than {limit, number} {limit, plural, one{pixel} other{pixels}}."]=>
string(219) "Файл «{file}» слишком маленький. Ширина должна быть более {limit, number} {limit, plural, one{пиксель} few{пикселя} many{пикселей} other{пикселя}}."
["The requested view "{name}" was not found."]=>
string(90) "Запрашиваемый файл представления "{name}" не найден."
["The verification code is incorrect."]=>
string(55) "Неправильный проверочный код."
["Total {count, number} {count, plural, one{item} other{items}}."]=>
string(128) "Всего {count, number} {count, plural, one{запись} few{записи} many{записей} other{записи}}."
["Unable to verify your data submission."]=>
string(73) "Не удалось проверить переданные данные."
["Unknown alias: -{name}"]=>
string(50) "Неизвестный псевдоним: -{name}"
["Unknown option: --{name}"]=>
string(43) "Неизвестная опция: --{name}"
["Update"]=>
string(26) "Редактировать"
["View"]=>
string(16) "Просмотр"
["Yes"]=>
string(4) "Да"
["Yii Framework"]=>
string(13) "Yii Framework"
["You are not allowed to perform this action."]=>
string(84) "Вам не разрешено производить данное действие."
["You can upload at most {limit, number} {limit, plural, one{file} other{files}}."]=>
string(157) "Вы не можете загружать более {limit, number} {limit, plural, one{файла} few{файлов} many{файлов} other{файла}}."
["in {delta, plural, =1{a day} other{# days}}"]=>
string(103) "через {delta, plural, =1{день} one{# день} few{# дня} many{# дней} other{# дня}}"
["in {delta, plural, =1{a minute} other{# minutes}}"]=>
string(125) "через {delta, plural, =1{минуту} one{# минуту} few{# минуты} many{# минут} other{# минуты}}"
["in {delta, plural, =1{a month} other{# months}}"]=>
string(125) "через {delta, plural, =1{месяц} one{# месяц} few{# месяца} many{# месяцев} other{# месяца}}"
["in {delta, plural, =1{a second} other{# seconds}}"]=>
string(135) "через {delta, plural, =1{секунду} one{# секунду} few{# секунды} many{# секунд} other{# секунды}}"
["in {delta, plural, =1{a year} other{# years}}"]=>
string(101) "через {delta, plural, =1{год} one{# год} few{# года} many{# лет} other{# года}}"
["in {delta, plural, =1{an hour} other{# hours}}"]=>
string(105) "через {delta, plural, =1{час} one{# час} few{# часа} many{# часов} other{# часа}}"
["just now"]=>
string(23) "прямо сейчас"
["the input value"]=>
string(35) "введённое значение"
["{attribute} "{value}" has already been taken."]=>
string(72) "Значение «{value}» для «{attribute}» уже занято."
["{attribute} cannot be blank."]=>
string(56) "Необходимо заполнить «{attribute}»."
["{attribute} contains wrong subnet mask."]=>
string(93) "Значение «{attribute}» содержит неверную маску подсети."
["{attribute} is invalid."]=>
string(48) "Значение «{attribute}» неверно."
["{attribute} is not a valid URL."]=>
string(80) "Значение «{attribute}» не является правильным URL."
["{attribute} is not a valid email address."]=>
string(97) "Значение «{attribute}» не является правильным email адресом."
["{attribute} is not in the allowed range."]=>
string(126) "Значение «{attribute}» не входит в список разрешенных диапазонов адресов."
["{attribute} must be "{requiredValue}"."]=>
string(86) "Значение «{attribute}» должно быть равно «{requiredValue}»."
["{attribute} must be a number."]=>
string(68) "Значение «{attribute}» должно быть числом."
["{attribute} must be a string."]=>
string(70) "Значение «{attribute}» должно быть строкой."
["{attribute} must be a valid IP address."]=>
string(94) "Значение «{attribute}» должно быть правильным IP адресом."
["{attribute} must be an IP address with specified subnet."]=>
string(93) "Значение «{attribute}» должно быть IP адресом с подсетью."
["{attribute} must be an integer."]=>
string(79) "Значение «{attribute}» должно быть целым числом."
["{attribute} must be either "{true}" or "{false}"."]=>
string(96) "Значение «{attribute}» должно быть равно «{true}» или «{false}»."
["{attribute} must be equal to "{compareValueOrAttribute}"."]=>
string(96) "Значение «{attribute}» должно быть равно «{compareValueOrAttribute}»."
["{attribute} must be greater than "{compareValueOrAttribute}"."]=>
string(115) "Значение «{attribute}» должно быть больше значения «{compareValueOrAttribute}»."
["{attribute} must be greater than or equal to "{compareValueOrAttribute}"."]=>
string(133) "Значение «{attribute}» должно быть больше или равно значения «{compareValueOrAttribute}»."
["{attribute} must be less than "{compareValueOrAttribute}"."]=>
string(115) "Значение «{attribute}» должно быть меньше значения «{compareValueOrAttribute}»."
["{attribute} must be less than or equal to "{compareValueOrAttribute}"."]=>
string(133) "Значение «{attribute}» должно быть меньше или равно значения «{compareValueOrAttribute}»."
["{attribute} must be no greater than {max}."]=>
string(76) "Значение «{attribute}» не должно превышать {max}."
["{attribute} must be no less than {min}."]=>
string(79) "Значение «{attribute}» должно быть не меньше {min}."
["{attribute} must not be a subnet."]=>
string(77) "Значение «{attribute}» не должно быть подсетью."
["{attribute} must not be an IPv4 address."]=>
string(80) "Значение «{attribute}» не должно быть IPv4 адресом."
["{attribute} must not be an IPv6 address."]=>
string(80) "Значение «{attribute}» не должно быть IPv6 адресом."
["{attribute} must not be equal to "{compareValueOrAttribute}"."]=>
string(101) "Значение «{attribute}» не должно быть равно «{compareValueOrAttribute}»."
["{attribute} should contain at least {min, number} {min, plural, one{character} other{characters}}."]=>
string(192) "Значение «{attribute}» должно содержать минимум {min, number} {min, plural, one{символ} few{символа} many{символов} other{символа}}."
["{attribute} should contain at most {max, number} {max, plural, one{character} other{characters}}."]=>
string(194) "Значение «{attribute}» должно содержать максимум {max, number} {max, plural, one{символ} few{символа} many{символов} other{символа}}."
["{attribute} should contain {length, number} {length, plural, one{character} other{characters}}."]=>
string(183) "Значение «{attribute}» должно содержать {length, number} {length, plural, one{символ} few{символа} many{символов} other{символа}}."
["{delta, plural, =1{1 day} other{# days}}"]=>
string(79) "{delta, plural, one{# день} few{# дня} many{# дней} other{# дня}}"
["{delta, plural, =1{1 hour} other{# hours}}"]=>
string(83) "{delta, plural, one{# час} few{# часа} many{# часов} other{# часа}}"
["{delta, plural, =1{1 minute} other{# minutes}}"]=>
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